Impact de la prophylaxie hormonale sur les fractures du fémur proximal des femmes postménopausiques: une étude de simulation. [Impact of hormonal prevention on fractures of the proximal femur in postmenopausal women: a simulation study].

Détails

ID Serval
serval:BIB_D59F0BD7D769
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impact de la prophylaxie hormonale sur les fractures du fémur proximal des femmes postménopausiques: une étude de simulation. [Impact of hormonal prevention on fractures of the proximal femur in postmenopausal women: a simulation study].
Périodique
Sozial- und Präventivmedizin
Auteur(s)
Van der Loos M., Paccaud F., Gutzwiller F., Chrzanowski R.
ISSN
0303-8408
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
33
Numéro
3
Pages
162-166
Langue
français
Résumé
A simulation model of the effects of hormone replacement therapy (HRT) on hip fractures and their consequences is based on a population of 100,000 post-menopausal women. This cohort is confronted with literature derived probabilities of cancers (endometrium or breast, which are contra-indications to HRT), hip fracture, disability requiring nursing home or home care, and death. Administration of HRT for life prevents 55,5% of hip fractures, 22,6% of years with home care and 4,4% of years in nursing homes. If HRT is administered for 15 years, these results are 15,5%, 10% and 2,2%, respectively. A slight gain in life expectancy is observed for both durations of HRT. The net financial loss in the simulated population is 222 million Swiss Francs (cost/benefit ratio 1.25) for lifelong administration of HRT, and 153 million Swiss Francs (cost/benefit ratio 1.42) if HRT is administered during 15 years.
Mots-clé
Aged , Aged, 80 and over , Estradiol Congeners/administration & dosage* , Female , Hip Fractures/mortality , Hip Fractures/prevention & control* , Humans , Menopause/drug effects , Middle Aged , Osteoporosis/prevention & control* , Risk Factors , Switzerland
Pubmed
Web of science
Création de la notice
09/08/2011 9:46
Dernière modification de la notice
20/08/2019 16:55
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