Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases

Détails

ID Serval
serval:BIB_D590500A91AA
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases
Titre de la conférence
98th Annual Congress of the Swiss Society of Surgery
Auteur(s)
Gervaz P., Gonzalez M., Robert J., Halkic N., Morel P., Ris H.B.
Adresse
Geneva, Switzerland, May 25-27, 2011
ISBN
0007-1323
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
98
Série
British Journal of Surgery
Pages
22
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Objective: Resection of hepatic metastases is indicated in selected Stage IV colorectal cancer (CRC) patients. A minority will eventually develop pulmonary metastases and may be candidates for lung surgery. The aim of this study was to assess clinical outcome, and identify parameters predicting survival after pulmonary metastasectomy, in patients who underwent prior resection of hepatic CRC metastases.Methods: We performed a retrospective analysis of 27 consecutive patients (median age 62 [range 33-75] years) who underwent resection of pulmonary metastases from CRC in two institutions from 1996 to 2009. All patients considered in the analysis had previously undergone colorectal and hepatic surgery with curative intent, and were considered cured in both locations (R0).Results: Median follow-up was 32 (range 3-69) months after resection of lung metastases and 65 (range 19-146) months after resection of primary CRC. Eleven (40?7%) patients had their primary tumors located in the rectum, and 12 (44%) patients presented initially with synchronous liver metastases (stage IV). Median disease-free interval between primary colorectal tumor and development of first metastasis was 6 (range 0-50) months. At the time of last follow-up, seven patients only (26%) were alive without evidence of recurrence. Three- and 5-year overall survival rates after lung surgery were 56% and 39%, respectively. Median survival after pulmonary metastasectomy was 46 months. In multivariate analysis, the number of pulmonary lesions was significantly correlated with survival (log-rank test, p = 0?035).Conclusion: Resection of lung metastases from CRC patients is compatible with prolonged (median = 4 years) survival, even when those patients had undergone prior resection of liver metastases. While prolonged, disease-free survival remains the exception, patients presentin
Mots-clé
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Web of science
Création de la notice
30/05/2011 9:47
Dernière modification de la notice
20/08/2019 16:55
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