Synapse formation on neurons born in the adult hippocampus.

Détails

ID Serval
serval:BIB_D584D388BEB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Synapse formation on neurons born in the adult hippocampus.
Périodique
Nature neuroscience
Auteur(s)
Toni N., Teng E.M., Bushong E.A., Aimone J.B., Zhao C., Consiglio A., van Praag H., Martone M.E., Ellisman M.H., Gage F.H.
ISSN
1097-6256
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
10
Numéro
6
Pages
727-734
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Although new and functional neurons are produced in the adult brain, little is known about how they integrate into mature networks. Here we explored the mechanisms of synaptogenesis on neurons born in the adult mouse hippocampus using confocal microscopy, electron microscopy and live imaging. We report that new neurons, similar to mature granule neurons, were contacted by axosomatic, axodendritic and axospinous synapses. Consistent with their putative role in synaptogenesis, dendritic filopodia were more abundant during the early stages of maturation and, when analyzed in three dimensions, the tips of all filopodia were found within 200 nm of preexisting boutons that already synapsed on other neurons. Furthermore, dendritic spines primarily synapsed on multiple-synapse boutons, suggesting that initial contacts were preferentially made with preexisting boutons already involved in a synapse. The connectivity of new neurons continued to change until at least 2 months, long after the formation of the first dendritic protrusions.
Mots-clé
Animals, Dendritic Spines/metabolism, Dendritic Spines/ultrastructure, Diagnostic Imaging/methods, Female, Hippocampus/cytology, Mice, Mice, Inbred C57BL, Microscopy, Confocal/methods, Microscopy, Electron, Transmission/methods, Models, Neurological, Neurons/cytology, Neurons/physiology, Organogenesis, Presynaptic Terminals, Synapses/physiology, Synapses/ultrastructure, Synaptic Transmission
Pubmed
Web of science
Création de la notice
22/01/2010 8:47
Dernière modification de la notice
20/08/2019 16:55
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