Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism

Détails

ID Serval
serval:BIB_D57CA3496BF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Bortolotti M., Rudelle S., Schneiter P., Vidal H., Loizon E., Tappy L., Acheson K. J.
ISSN
0002-9165
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
88
Numéro
4
Pages
877-885
Langue
anglais
Résumé
BACKGROUND: Dairy calcium supplementation has been proposed to increase fat oxidation and to inhibit lipogenesis. OBJECTIVE: We aimed to investigate the effects of calcium supplementation on markers of fat metabolism. DESIGN: In a placebo-controlled, crossover experiment, 10 overweight or obese subjects who were low calcium consumers received 800 mg dairy Ca/d for 5 wk. After 4 wk, adipose tissue was taken for biopsy for analysis of gene expression. Respiratory exchange, glycerol turnover, and subcutaneous adipose tissue microdialysis were performed for 7 h after consumption of 400 mg Ca or placebo, and the ingestion of either randomized slow-release caffeine (SRC; 300 mg) or lactose (500 mg). One week later, the test was repeated with the SRC or lactose crossover. RESULTS: Calcium supplementation increased urinary calcium excretion by 16% (P = 0.017) but did not alter plasma parathyroid hormone or osteocalcin concentrations. Resting energy expenditure (59.9 +/- 3.0 or 59.6 +/- 3.3 kcal/h), fat oxidation (58.4 +/- 2.5 or 53.8 +/- 2.2 mg/min), plasma free fatty acid concentrations (0.63 +/- 0.02 or 0.62 +/- 0.03 mmol/L), and glycerol turnover (3.63 +/- 0.41 or 3.70 +/- 0.38 micromol . kg(-1) . min(-1)) were similar with or without calcium, respectively. SRC significantly increased free fatty acid concentrations, resting fat oxidation, and resting energy expenditure. During microdialysis, epinephrine increased dialysate glycerol concentrations by 250% without and 254% with calcium. Expression of 7 key metabolic genes in subcutaneous adipose tissue was not affected by calcium supplementation. CONCLUSION: Dairy calcium supplementation in overweight subjects with habitually low calcium intakes failed to alter fat metabolism and energy expenditure under resting conditions and during acute stimulation by caffeine or epinephrine
Mots-clé
Adipose Tissue , administration & dosage , Adult , analysis , Basal Metabolism , Biological Markers , Biopsy , blood , Caffeine , Calcium , Calcium,Dietary , Cross-Over Studies , Dairy Products , Double-Blind Method , drug effects , Energy Metabolism , Epinephrine , Fatty Acids,Nonesterified , Female , Glycerol , Humans , Lactose , Lipid Metabolism , Male , metabolism , Microdialysis , Obesity , Osteocalcin , Overweight , Oxidation-Reduction , Oxygen Consumption , Parathyroid Hormone , pharmacology , physiology , RNA,Messenger , Switzerland , urine
Pubmed
Web of science
Création de la notice
29/01/2009 23:13
Dernière modification de la notice
20/08/2019 16:55
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