Nouveau spectre des troubles cognitifs liés à l'infection par le VIH à l'ère des trithérapies [New spectrum of HIV-associated cognitive disorders in the HAART era]

Détails

ID Serval
serval:BIB_D5742DE8F1D4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nouveau spectre des troubles cognitifs liés à l'infection par le VIH à l'ère des trithérapies [New spectrum of HIV-associated cognitive disorders in the HAART era]
Périodique
Revue Médicale Suisse
Auteur(s)
Du Pasquier R., Cavassini M., Simioni S., Annoni J.M., Giacobini E., Hirschel B.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2009
Volume
5
Numéro
201
Pages
955-956, 958-961
Langue
français
Résumé
Highly active anti-retroviral therapy (HAART) has almost abolished HIV-related mortality and serious opportunistic diseases; among them, AIDS-related dementia. However, minor forms of cognitive dysfunction, have not disappeared, and even increased in frequency. Ageing of HIV+ patients, insufficient penetration of anti-viral drugs into the brain with continuous low-grade viral production and inflammation may play a role. Minor cognitive dysfunction in HIV infection shares some clinical and pathophysiological features with neuro-degenerative diseases, in particular Alzheimers disease. It can thus be postulated that, such in Alzheimer disease, anti-cholinesterase drugs might also be efficacious in AIDS-related minor cognitive dysfunction. This hypothesis has not been tested yet however A clinical trial using ravistigmine is starting this spring in patients with HIV-associated cognitive dysfunction in Geneva and Lausanne.
Mots-clé
Algorithms, Antiretroviral Therapy, Highly Active, Cognition Disorders/etiology, HIV Infections/complications, HIV Infections/drug therapy, Humans
Pubmed
Création de la notice
03/09/2009 8:36
Dernière modification de la notice
20/08/2019 16:55
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