Does laser injury induce a different neovascularisation pattern from mechanical or ischaemic injuries?

Détails

ID Serval
serval:BIB_D5703C0E8479
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Does laser injury induce a different neovascularisation pattern from mechanical or ischaemic injuries?
Périodique
Heart
Auteur(s)
Mueller  X. M., Tevaearai  H. T., Chaubert  P., Genton  C. Y., von Segesser  L. K.
ISSN
1468-201X
Statut éditorial
Publié
Date de publication
06/2001
Peer-reviewed
Oui
Volume
85
Numéro
6
Pages
697-701
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jun
Résumé
AIM: To analyse the arteriolar pattern of laser induced channels and their surroundings compared with mechanical and ischaemic injury. METHODS: 24 pigs were randomised to a myocardial infarction group, a transmyocardial laser revascularisation group, a needle group, or a control group. In the laser revascularisation and needle groups, five channels were created either with a 1.75 mm probe holmium-YAG laser or a Tru-cut needle of the same size. Animals were killed 28 days later. Morphometric analysis of vascular density was expressed as the mean (SD) number of arteriolar structures/cm(2). RESULTS: Laser and needle channels were completely invaded by granulation tissue. Their surface areas did not differ significantly: 2.28 (0.7) mm(2) and 2.38 (1.1) mm(2), respectively (p = 0.82). Within both types of channel, arteriolar density was significantly increased in comparison with the myocardial infarction scar: 197 (52)/cm(2) and 190 (64)/cm(2), respectively (p = 0.8) versus 56 (20)/cm(2) (p < 0.001 for both comparisons). The area of 1 mm width immediately adjacent to the laser and needle channels showed a density of 25 (16)/cm(2) and 23 (18)/cm(2), respectively, which is similar to that of normal tissue (28 (10)/cm(2); p = 0.6 and p = 0.4, respectively). The mean arteriolar diameter was similar throughout all the regions analysed. CONCLUSIONS: Both laser and needle channels produce a similar increase in arteriolar structures, which is limited to the lesion itself. This suggests that laser injury is not more potent as an angiogenic stimulator than mechanical injury, which in turn is superior to infarction.
Mots-clé
Animals Disease Models, Animal Heart Injuries/pathology Laser Therapy/*adverse effects Myocardial Infarction/*pathology/surgery Myocardial Revascularization/*adverse effects Myocardium/*pathology Needles Neovascularization, Pathologic/etiology/*pathology Swine
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
20/08/2019 16:55
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