Vaccination against Helicobacter pylori--an old companion of man

Détails

ID Serval
serval:BIB_D560A1092416
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Vaccination against Helicobacter pylori--an old companion of man
Périodique
Expert Opinion on Biological Therapy
Auteur(s)
Keller  W. C., Michetti  P.
ISSN
1471-2598 (Print)
Statut éditorial
Publié
Date de publication
09/2001
Volume
1
Numéro
5
Pages
795-802
Notes
Journal Article
Review --- Old month value: Sep
Résumé
Helicobacter pylori infection induces an important systemic and mucosal antibody response and a predominant Th1 cellular response. These immune responses, although powerful, fail to eliminate the infection. Studies in animals have shown that prophylactic and therapeutic immunisations are efficacious, although complete protective immunity has usually not been achieved. Initial human trials with recombinant urease showed that a mucosal immune response can be obtained following immunisations, with a decrease in bacterial density, but successful immunisation is still awaited. Progress is being made in several areas of vaccine design. A human vaccine against H. pylori would be favourable in terms of health benefits and costs in developed and developing countries.
Mots-clé
Animals Bacterial Vaccines/*therapeutic use Helicobacter Infections/immunology/*prevention & control Helicobacter pylori/drug effects/*immunology Humans Vaccination/*methods
Pubmed
Web of science
Création de la notice
25/01/2008 17:02
Dernière modification de la notice
20/08/2019 16:55
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