Models of immune selection for multi-locus antigenic diversity of pathogens.

Détails

ID Serval
serval:BIB_D5234C658C56
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Models of immune selection for multi-locus antigenic diversity of pathogens.
Périodique
Nature reviews. Immunology
Auteur(s)
Georgieva M., Buckee C.O., Lipsitch M.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
01/2019
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
55-62
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
It is well accepted that pathogens can evade recognition and elimination by the host immune system by varying their antigenic targets. Thus, it has become a truism that host immunity is a major driver and determinant of the antigenic diversity of pathogens. However, it remains puzzling how host immunity selects for antigenic diversity at the level of the pathogen population, given that hosts have acquired immune responses to multiple antigens of most pathogens - sometimes through multiple effectors of both humoral and cellular immunity. In this Opinion article, we address this puzzle and the related question of why pathogens often have diversity at multiple antigenic loci. Here, we describe five hypotheses to explain the polymorphism of multiple antigens in a single pathogen species and highlight research relevant to our current models of thinking about multi-locus antigenic diversity.
Pubmed
Web of science
Création de la notice
04/01/2019 15:06
Dernière modification de la notice
21/08/2019 6:35
Données d'usage