Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases

Détails

ID Serval
serval:BIB_D4FC3F516DB1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases
Périodique
Arthritis and Rheumatism
Auteur(s)
Frances  C., Niang  S., Laffitte  E., Pelletier  F., Costedoat  N., Piette  J. C.
ISSN
0004-3591 (Print)
Statut éditorial
Publié
Date de publication
06/2005
Volume
52
Numéro
6
Pages
1785-93
Notes
Journal Article --- Old month value: Jun
Résumé
OBJECTIVE: To describe dermatologic manifestations of the antiphospholipid syndrome (APS) and to investigate possible correlations between livedo reticularis and other APS manifestations. METHODS: We conducted a single-center study of 200 consecutive patients with primary or systemic lupus erythematosus-related APS. To qualify for the study, patients had to fulfill clinical and laboratory criteria from the most recent international consensus statement on classification of definite APS. Dermatologic manifestations were systematically evaluated by a dermatologist. Only dermatologic lesions that may be related to APS were included in the analyses. Correlations between livedo reticularis and other APS manifestations were determined using Fisher's 2-tailed, chi-square, and nonparametric Mann-Whitney tests. RESULTS: Dermatologic manifestations were noted in 49% of the patients and were the presenting manifestations in 30.5%. Livedo reticularis was the most frequent manifestation, observed in 25.5% of the patients. Livedo reticularis was shown to be significantly associated with cerebral or ocular ischemic arterial events (odds ratio [OR] 10.8, 95% confidence interval [95% CI] 5.2-22.5), seizures (OR 6.5, 95% CI 2.6-16), all arterial events (OR 6, 95% CI 2.9-12.6), heart valve abnormalities detected on echocardiography (OR 7.3, 95% CI 3.6-14.7), and arterial systemic hypertension (>/=160/90 mm Hg) (OR 2.9, 95% CI 1.5-5.7). Conversely, it was observed with decreased frequency in patients with only venous thrombosis (OR 0.2, 95% CI 0.1-0.5). CONCLUSION: The dermatologic manifestations of APS are frequently the presenting feature of the syndrome, and livedo reticularis is significantly associated with the arterial subset of APS.
Mots-clé
Adolescent Adult Aged Antiphospholipid Syndrome/*immunology Child Female Humans Lupus Erythematosus, Systemic/complications/immunology Male Middle Aged Skin Diseases/immunology Skin Diseases, Vascular/*immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:41
Dernière modification de la notice
20/08/2019 15:54
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