Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study
Détails
ID Serval
serval:BIB_D4C2AE7FB208
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study
Périodique
American journal of psychiatry
ISSN
0002-953X
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
157
Numéro
6
Pages
948-955
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Multicenter Study ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: Although genetic factors have been implicated in the etiology of bipolar disorder, no specific gene has been conclusively identified. Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. METHOD: In France and Switzerland, 272 patients with bipolar disorder and 122 healthy subjects were typed for three polymorphic markers of the MAOA gene: the MAOA-CA repeat, the MAOA restriction fragment length polymorphism (RFLP), and a repeat directly adjacent to the variable number of tandem repeats (VNTR) locus. RESULTS: A significant difference in the distribution of the alleles for the MAOA-CA repeat was observed between the female bipolar patients and comparison group. CONCLUSIONS: The results obtained in the French and Swiss population confirm findings from two studies conducted in the United Kingdom.
Mots-clé
Adult, Alleles, Bipolar Disorder, Female, Genetic Markers, Genotype, Humans, Male, Middle Aged, Monoamine Oxidase, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Psychiatric Status Rating Scales, Sex Factors, Tandem Repeat Sequences
Pubmed
Web of science
Création de la notice
10/03/2008 11:24
Dernière modification de la notice
20/08/2019 16:54