Autoimmunity in Wiskott-Aldrich syndrome

Détails

ID Serval
serval:BIB_D46D86B0E405
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Autoimmunity in Wiskott-Aldrich syndrome
Périodique
Curr Opin Rheumatol
Auteur⸱e⸱s
Schurman S. H., Candotti F.
ISSN
1040-8711 (Print)
ISSN-L
1040-8711
Statut éditorial
Publié
Date de publication
07/2003
Volume
15
Numéro
4
Pages
446-53
Langue
anglais
Notes
Schurman, Shepherd H
Candotti, Fabio
eng
Review
Curr Opin Rheumatol. 2003 Jul;15(4):446-53.
Résumé
As many as 40% of patients with Wiskott-Aldrich syndrome may eventually suffer from an autoimmune disorder, with an increased chance of developing a malignancy. Vasculitides and autoimmune hemolytic anemia are the two most common autoimmune manifestations and often cause considerable morbidity and mortality, because they may require treatment with bone marrow transplantation. Insights into the mechanisms of autoimmunity have provided clues to the pathogenesis of these disorders in Wiskott-Aldrich syndrome. Chronic inflammation, interleukin-2 deficiency, and increased apoptosis may all play a possible role in the loss of peripheral tolerance to self-antigens in this disease. This article reviews the manifestations and consequences of autoimmunity in Wiskott-Aldrich syndrome, its possible mechanisms, and available treatments.
Mots-clé
Autoimmune Diseases/*genetics/pathology, Autoimmunity/*immunology, Humans, Wiskott-Aldrich Syndrome/*immunology/pathology
Pubmed
Création de la notice
01/11/2017 10:29
Dernière modification de la notice
20/08/2019 15:54
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