Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.

Détails

ID Serval
serval:BIB_D45F483784E1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes.
Périodique
Current Drug Targets
Auteur(s)
Martin J.L., Magistretti P.J., Allaman I.
ISSN
1873-5592 (Electronic)
ISSN-L
1389-4501
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
14
Numéro
11
Pages
1308-1321
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish Journal Article. Research Support, Non-U.S. Gov't. Review.
Résumé
There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of several astrocytic markers suggesting that astrocyte dysfunction may contribute to the pathophysiology of major depression. In rodents, glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors and antidepressant treatment prevents the stress-induced reduction of astrocyte number in the hippocampus. Collectively, these data support the existence of a link between astrocyte loss or dysfunction, depressive-like behavior and antidepressant treatment. Astrocytes are increasingly recognized to play important roles in neuronal development, neurotransmission, synaptic plasticity and maintenance of brain homeostasis. It is also well established that astrocytes provide trophic, structural, and metabolic support to neurons. In this article, we review evidence that antidepressants regulate energy metabolism and neurotrophic factor expression with particular emphasis on studies in astrocytes. These observations support a role for astrocytes as new targets for antidepressants. The contribution of changes in astrocyte glucose metabolism and neurotrophic factor expression to the therapeutic effects of antidepressants remains to be established.
Mots-clé
Animals, Antidepressive Agents/pharmacology, Antidepressive Agents/therapeutic use, Astrocytes/drug effects, Astrocytes/metabolism, Depressive Disorder, Major/drug therapy, Depressive Disorder, Major/physiopathology, Disease Models, Animal, Energy Metabolism/drug effects, Gene Expression Regulation, Humans, Nerve Growth Factors/genetics, Nerve Growth Factors/metabolism, Rodentia, Stress, Psychological/drug therapy, Stress, Psychological/physiopathology, Synaptic Transmission/drug effects
Pubmed
Web of science
Création de la notice
25/05/2014 14:55
Dernière modification de la notice
09/09/2019 5:26
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