Repair and recovery following spinal cord injury in a neonatal marsupial (Monodelphis domestica)

Détails

ID Serval
serval:BIB_D43C0261B9B0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Repair and recovery following spinal cord injury in a neonatal marsupial (Monodelphis domestica)
Périodique
Clinical and Experimental Pharmacology and Physiology
Auteur(s)
Saunders  N. R., Deal  A., Knott  G. W., Varga  Z. M., Nicholls  J. G.
ISSN
0305-1870 (Print)
Statut éditorial
Publié
Date de publication
08/1995
Volume
22
Numéro
8
Pages
518-26
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
1. Repair and recovery following spinal cord injury (complete spinal cord crush) has been studied in vitro in neonatal opossum (Monodelphis domestica), fetal rat and in vivo in neonatal opossum. 2. Crush injury of the cultured spinal cord of isolated entire central nervous system (CNS) of neonatal opossum (P4-10) or fetal rats (E15-E16) was followed by profuse growth of fibres and recovery of conduction of impulses through the crush. Previous studies of injured immature mammalian spinal cord have described fibre growth occurring only around the lesion, unless implanted with fetal CNS. 3. The period during which successful growth occurred in response to a crush is developmentally regulated. No such growth was obtained after P12 in spinal cords crushed in vitro at the level of C7-8. 4. In vivo, in the neonatal (P4-8) marsupial opossum, growth of fibres through, and restoration of, impulse conduction across the crush was apparent 1-2 weeks after injury. With longer periods of time after crushing a considerable degree of normal locomotor function developed. 5. By the time the operated animals reached adulthood, the morphological structure of the spinal cord, both in the region of the crush and on either side of the site of the lesion, appeared grossly normal. 6. The results are discussed in relation to the eventual longterm possibility of devising effective treatments for patients with spinal cord injuries.
Mots-clé
Animals Animals, Newborn/*physiology Behavior, Animal/physiology Carbocyanines Electrophysiology Female Fluorescent Dyes Immunohistochemistry Microscopy, Electron Neural Conduction/physiology Neurons/physiology/ultrastructure Opossums/*physiology Pregnancy Spinal Cord/pathology Spinal Cord Injuries/pathology/*physiopathology/psychology
Pubmed
Web of science
Création de la notice
24/01/2008 15:26
Dernière modification de la notice
20/08/2019 16:54
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