The role of ubiquitin-proteasome system in glioma survival and growth.

Détails

ID Serval
serval:BIB_D429F381C7CE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of ubiquitin-proteasome system in glioma survival and growth.
Périodique
Growth Factors
Auteur⸱e⸱s
Vlachostergios P.J., Voutsadakis I.A., Papandreou C.N.
ISSN
1029-2292 (Electronic)
ISSN-L
0897-7194
Statut éditorial
Publié
Date de publication
2013
Volume
31
Numéro
3
Pages
106-113
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish. pdf type: review
Résumé
High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery responsible for protein turnover. Emerging evidence implicates various proteins targeted for degradation by the UPS in key survival and proliferation signaling pathways of these tumors. In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas.
Mots-clé
Animals, Brain Neoplasms/enzymology, Brain Neoplasms/metabolism, Cell Proliferation, Cell Survival, Glioma/enzymology, Glioma/metabolism, Humans, Intercellular Signaling Peptides and Proteins/metabolism, Proteasome Endopeptidase Complex/metabolism, Transcription Factors/metabolism, Ubiquitin/metabolism
Pubmed
Web of science
Création de la notice
11/07/2013 20:01
Dernière modification de la notice
20/08/2019 15:54
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