Worse pulmonary function in association with cumulative exposure to nanomaterials. Hints of a mediation effect via pulmonary inflammation.

Détails

ID Serval
serval:BIB_D3FA75922862
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Worse pulmonary function in association with cumulative exposure to nanomaterials. Hints of a mediation effect via pulmonary inflammation.
Périodique
Particle and fibre toxicology
Auteur⸱e⸱s
Squillacioti G., Charreau T., Wild P., Bellisario V., Ghelli F., Bono R., Bergamaschi E., Garzaro G., Guseva Canu I.
ISSN
1743-8977 (Electronic)
ISSN-L
1743-8977
Statut éditorial
Publié
Date de publication
28/06/2024
Peer-reviewed
Oui
Volume
21
Numéro
1
Pages
28
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: epublish
Résumé
Today, nanomaterials are broadly used in a wide range of industrial applications. Such large utilization and the limited knowledge on to the possible health effects have raised concerns about potential consequences on human health and safety, beyond the environmental burden. Given that inhalation is the main exposure route, workers exposed to nanomaterials might be at risk of occurrence of respiratory morbidity and/or reduced pulmonary function. However, epidemiological evidence regarding the association between cumulative exposure to nanomaterials and respiratory health is still scarce. This study focused on the association between cumulative exposure to nanomaterials and pulmonary function among 136 workers enrolled in the framework of the European multicentric NanoExplore project.
Our findings suggest that, independently of lifelong tobacco smoking, ethnicity, age, sex, body mass index and physical activity habits, 10-year cumulative exposure to nanomaterials is associated to worse FEV <sub>1</sub> and FEF <sub>25 - 75%</sub> , which might be consistent with the involvement of both large and small airway components and early signs of airflow obstruction. We further explored the hypothesis of a mediating effect via airway inflammation, assessed by interleukin (IL-)10, IL-1β and Tumor Necrosis Factor alpha (TNF-α), all quantified in the Exhaled Breath Condensate of workers. The mediation analysis results suggest that IL-10, TNF-α and their ratio (i.e., anti-pro inflammatory ratio) may fully mediate the negative association between cumulative exposure to nanomaterials and the FEV <sub>1</sub> /FVC ratio. This pattern was not observed for other pulmonary function parameters.
Safeguarding the respiratory health of workers exposed to nanomaterials should be of primary importance. The observed association between cumulative exposure to nanomaterials and worse pulmonary function parameters underscores the importance of implementing adequate protective measures in the nanocomposite sector. The mitigation of harmful exposures may ensure that workers can continue to contribute productively to their workplaces while preserving their respiratory health over time.
Mots-clé
Humans, Male, Nanostructures/toxicity, Female, Occupational Exposure/adverse effects, Adult, Inhalation Exposure/adverse effects, Middle Aged, Lung/drug effects, Lung/physiopathology, Lung/immunology, Pneumonia/chemically induced, Forced Expiratory Volume, Respiratory Function Tests, Cytokines/metabolism, Air Pollutants, Occupational/toxicity, Europe, Biomarkers, Exhaled breath condensate, Inflammation, Nanomaterials, Occupational health, Public health, Pulmonary function, Spirometry
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/07/2024 8:07
Dernière modification de la notice
12/07/2024 7:04
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