Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men

Détails

ID Serval
serval:BIB_D3BC0046AF30
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men
Périodique
American Journal of Respiratory and Critical Care Medicine
Auteur⸱e⸱s
Riediker Michael, Cascio Wayne E., Griggs Thomas R., Herbst Margaret C., Bromberg Philip A., Neas Lucas, Williams Ronald W., Devlin Robert B.
ISSN
1073-449X
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
169
Numéro
8
Pages
934-940
Langue
anglais
Notes
SAPHIRID:49658
Résumé
Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troopers (age 23 to 30) were monitored on 4 successive days while working a 3 P.M. to midnight shift. Each patrol car was equipped with air-quality monitors. Blood was drawn 14 hours after each shift, and ambulatory monitors recorded the electrocardiogram throughout the shift and until the next morning. Data were analyzed using mixed models. In-vehicle PM(2.5) (average of 24 microg/m(3)) was associated with decreased lymphocytes (-11% per 10 microg/m(3)) and increased red blood cell indices (1% mean corpuscular volume), neutrophils (6%), C-reactive protein (32%), von Willebrand factor (12%), next-morning heart beat cycle length (6%), next-morning heart rate variability parameters, and ectopic beats throughout the recording (20%). Controlling for potential confounders had little impact on the effect estimates. The associations of these health endpoints with ambient and roadside PM(2.5) were smaller and less significant. The observations in these healthy young men suggest that in-vehicle exposure to PM(2.5) may cause pathophysiologic changes that involve inflammation, coagulation, and cardiac rhythm.
Pubmed
Web of science
Création de la notice
12/05/2009 13:43
Dernière modification de la notice
20/08/2019 16:53
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