Myocardial delayed enhancement in paucisymptomatic nonischemic dilated cardiomyopathy.

Détails

ID Serval
serval:BIB_D38CE1CCB4C6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Myocardial delayed enhancement in paucisymptomatic nonischemic dilated cardiomyopathy.
Périodique
International journal of cardiology
Auteur⸱e⸱s
Masci P.G., Barison A., Aquaro G.D., Pingitore A., Mariotti R., Balbarini A., Passino C., Lombardi M., Emdin M.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Statut éditorial
Publié
Date de publication
17/05/2012
Peer-reviewed
Oui
Volume
157
Numéro
1
Pages
43-47
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We investigated the prognostic role of myocardial fibrosis by delayed enhancement (DE) cardiovascular magnetic resonance (CMR) in nonischemic dilated cardiomyopathy (NICM) patients with no or mild symptoms of heart failure (HF).
A prospective cohort of 125 NICM patients (82 males, age 59±14years, mean±SD) with echocardiographic evidence of left ventricular (LV) systolic dysfunction (mean ejection-fraction 33±10%), without (stage B) or with history of mild HF symptoms (stage C, NYHA classes I-II) was enrolled. The end-point was a composite of cardiac death and HF hospitalization.
Fifty (40%) patients showed myocardial DE, representing 12±7% of LV mass. During a median follow-up of 14.2months, 16 (32%) patients with DE experienced a composite event versus only 6 (8%) patients without DE (Kaplan-Meier survival curve, p=0.001). After correction for age, CMR-derived LV and right ventricular volumes, echocardiographic measurements of LV diastolic function and Doppler-estimated systolic pulmonary artery pressure, the presence of DE remained a strong and independent predictor of cardiac death or HF hospitalization (hazard ratio: 5.32, 95% confidence intervals 1.60 to 17.63, p=0.006).
In NICM patients with no or mild HF symptoms, the presence of myocardial DE is a strong predictor of worse clinical outcome even after correction for other established prognostic determinants. Contrast-enhanced CMR may be useful in prognostic stratification from the early stages of NICM.

Mots-clé
Aged, Cardiomyopathy, Dilated/diagnostic imaging, Cardiomyopathy, Dilated/mortality, Cardiomyopathy, Dilated/physiopathology, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardium/pathology, Prospective Studies, Survival Rate/trends, Ultrasonography
Pubmed
Web of science
Création de la notice
25/08/2017 20:50
Dernière modification de la notice
20/08/2019 15:53
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