Targeted destabilization of HY5 during light-regulated development of Arabidopsis

Détails

ID Serval
serval:BIB_D37BF54809E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Targeted destabilization of HY5 during light-regulated development of Arabidopsis
Périodique
Nature
Auteur(s)
Osterlund  M. T., Hardtke  C. S., Wei  N., Deng  X. W.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
05/2000
Volume
405
Numéro
6785
Pages
462-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: May 25
Résumé
Arabidopsis seedlings display contrasting developmental patterns depending on the ambient light. Seedlings grown in the light develop photomorphogenically, characterized by short hypocotyls and expanded green cotyledons. In contrast, seedlings grown in darkness become etiolated, with elongated hypocotyls and dosed cotyledons on an apical hook. Light signals, perceived by multiple photoreceptors and transduced to downstream regulators, dictate the extent of photomorphogenic development in a quantitative manner. Two key downstream components, COP1 and HY5, act antagonistically in regulating seedling development. HY5 is a bZIP transcription factor that binds directly to the promoters of light-inducible genes, promoting their expression and photomorphogenic development. COP1 is a RING-finger protein with WD-40 repeats whose nuclear abundance is negatively regulated by light. COP1 interacts directly with HY5 in the nucleus to regulate its activity negatively. Here we show that the abundance of HY5 is directly correlated with the extent of photomorphogenic development, and that the COP1-HY5 interaction may specifically target HY5 for proteasome-mediated degradation in the nucleus.
Mots-clé
Arabidopsis/*growth & development/radiation effects *Arabidopsis Proteins Basic-Leucine Zipper Transcription Factors Carrier Proteins/physiology Cysteine Endopeptidases/metabolism Darkness Light Molecular Sequence Data Multienzyme Complexes/metabolism Nuclear Proteins/genetics/metabolism/*physiology Photosynthetic Reaction Center Complex Proteins/metabolism Plant Proteins/genetics/*physiology Plants, Genetically Modified Proteasome Endopeptidase Complex RNA, Messenger/metabolism *Ubiquitin-Protein Ligases
Pubmed
Web of science
Création de la notice
24/01/2008 19:51
Dernière modification de la notice
20/08/2019 15:53
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