A molecular basis for MHC class II--associated autoimmunity.

Détails

ID Serval
serval:BIB_D3698A9BB0E2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A molecular basis for MHC class II--associated autoimmunity.
Périodique
Science
Auteur(s)
Todd J.A., Acha-Orbea H., Bell J.I., Chao N., Fronek Z., Jacob C.O., McDermott M., Sinha A.A., Timmerman L., Steinman L., Mc-Devitt H. O.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
1988
Volume
240
Numéro
4855
Pages
1003-1009
Langue
anglais
Résumé
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.
Mots-clé
Amino Acid Sequence, Arthritis, Rheumatoid/immunology, Autoantibodies/genetics, Autoimmune Diseases/genetics, Diabetes Mellitus, Type 1/immunology, HLA-D Antigens/genetics, Humans, Major Histocompatibility Complex, Molecular Sequence Data, Pemphigus/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 15:53
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