Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_D318FD13ECFC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients.
Périodique
Frontiers in medicine
Auteur(s)
Guihur A., Rebeaud M.E., Fauvet B., Tiwari S., Weiss Y.G., Goloubinoff P.
ISSN
2296-858X (Print)
ISSN-L
2296-858X
Statut éditorial
Publié
Date de publication
2020
Peer-reviewed
Oui
Volume
7
Pages
564170
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Mortality in COVID-19 patients predominantly results from an acute respiratory distress syndrome (ARDS), in which lungs alveolar cells undergo programmed cell death. Mortality in a sepsis-induced ARDS rat model is reduced by adenovirus over-expression of the HSP70 chaperone. A natural rise of body temperature during mild fever can naturally accumulate high cellular levels of HSP70 that can arrest apoptosis and protect alveolar lung cells from inflammatory damages. However, beyond 1-2 h of fever, no HSP70 is being further produced and a decreased in body temperature required to the restore cell's ability to produce more HSP70 in a subsequent fever cycle. We suggest that antipyretics may be beneficial in COVID-19 patients subsequent to several hours of mild (<38.8°C) advantageous fever, allowing lung cells to accumulate protective HSP70 against damages from the inflammatory response to the virus SARS-CoV-2. With age, the ability to develop fever and accumulate HSP70 decreases. This could be ameliorated, when advisable to do so, by thermotherapies and/or physical training.
Mots-clé
COVID-19, Hsp70, SARS-CoV-2, acute respiratory distress syndrome, fever, heat- shock response
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse
Création de la notice
21/09/2020 20:24
Dernière modification de la notice
15/01/2021 7:12
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