A microRNA switch regulates the rise in hypothalamic GnRH production before puberty.
Détails
ID Serval
serval:BIB_D2DE5F6E4CC3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A microRNA switch regulates the rise in hypothalamic GnRH production before puberty.
Périodique
Nature Neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
19
Numéro
6
Pages
835-844
Langue
anglais
Résumé
A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the 'master molecule' gonadotropin-releasing hormone (GnRH). Timely postnatal changes in GnRH expression are essential for puberty and adult fertility. Here we report that a multilayered microRNA-operated switch with built-in feedback governs increased GnRH expression during the infantile-to-juvenile transition and that impairing microRNA synthesis in GnRH neurons leads to hypogonadotropic hypogonadism and infertility in mice. Two essential components of this switch, miR-200 and miR-155, respectively regulate Zeb1, a repressor of Gnrh transcriptional activators and Gnrh itself, and Cebpb, a nitric oxide-mediated repressor of Gnrh that acts both directly and through Zeb1, in GnRH neurons. This alteration in the delicate balance between inductive and repressive signals induces the normal GnRH-fuelled run-up to correct puberty initiation, and interfering with this process disrupts the neuroendocrine control of reproduction.
Pubmed
Web of science
Création de la notice
26/06/2016 15:37
Dernière modification de la notice
07/08/2022 14:50