Rôle du peptide atrial natriurétique dans la réponse rénale à l'expansion volémique aiguë chez le sujet normal et l'hypertendu essentiel [Role of atrial natriuretic peptide in the renal response to acute volume expansion in the normal and essential hypertensive patient]

Détails

ID Serval
serval:BIB_D2C314729914
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rôle du peptide atrial natriurétique dans la réponse rénale à l'expansion volémique aiguë chez le sujet normal et l'hypertendu essentiel [Role of atrial natriuretic peptide in the renal response to acute volume expansion in the normal and essential hypertensive patient]
Périodique
Archives des Maladies du Coeur et des Vaisseaux
Auteur⸱e⸱s
Mimran A., Nussberger J., Ribstein J., Waeber B., Brunner H.R.
ISSN
0003-9683
Statut éditorial
Publié
Date de publication
06/1988
Peer-reviewed
Oui
Volume
81 Spec. No
Pages
101-104
Langue
français
Notes
English Abstract Journal Article --- Old month value: Jun
Résumé
An exaggerated natriuretic response to volume expansion (VE) is observed in many essential hypertensive patients. The plasma levels of atrial natriuretic peptide (ANP) were measured in 11 normal subjects (NT) and 12 patients with mild essential hypertension (EH) during VE (1 800 ml isotonic saline IV over 3 hours). NT and EH groups were similar with respect to age and basal levels of renin, aldosterone and ANP (34.5 +/- 5.5 in NT and 32.5 +/- 6.3 pg/ml in EH, mean +/- sem). In response to VE, ANP increased to the same extent in both groups (a change of + 19.3 +/- 5.2 in NT and 22.2 +/- 7.1 pg/ml in EH) despite the marked difference in observed natriuresis (36 +/- 3.5 in NT and 54.9 +/- 6.3 mmol/3 in EH, p less than 0.02). The change in ANP induced by VE was inversely correlated with the fall in hematocrit and the variation in fractional excretion of sodium in both groups. These results suggest that atrial natriuretic peptide may participate in the control of the renal response to isotonic volume expansion, but they do not support a predominant role of atrial natriuretic peptide in the exaggerated natriuretic responses to volume expansion of patients with essential hypertension.
Mots-clé
Adult, Aldosterone/blood, Atrial Natriuretic Factor/physiology, Blood Volume, Female, Humans, Hypertension/physiopathology, Male, Middle Aged, Natriuresis, Renin/blood, Sodium Chloride, Solutions
Pubmed
Web of science
Création de la notice
05/03/2008 16:40
Dernière modification de la notice
20/08/2019 15:52
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