Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research.

Détails

Ressource 1Télécharger: BIB_D2BD1C58B933.P001.pdf (879.63 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_D2BD1C58B933
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research.
Périodique
Clinical Microbiology Reviews
Auteur(s)
Vasilevsky S., Greub G., Nardelli-Haefliger D., Baud D.
ISSN
1098-6618 (Electronic)
ISSN-L
0893-8512
Statut éditorial
Publié
Date de publication
2014
Volume
27
Numéro
2
Pages
346-370
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine has yet to be developed. This Gram-negative obligate intracellular bacterium, which often causes asymptomatic infection, may cause pelvic inflammatory disease (PID), ectopic pregnancies, scarring of the fallopian tubes, miscarriage, and infertility when left untreated. In the genital tract, Chlamydia trachomatis infects primarily epithelial cells and requires Th1 immunity for optimal clearance. This review first focuses on the immune cells important in a chlamydial infection. Second, we summarize the research and challenges associated with developing a chlamydial vaccine that elicits a protective Th1-mediated immune response without inducing adverse immunopathologies.
Mots-clé
Adaptive Immunity, Bacterial Vaccines/immunology, Bacterial Vaccines/isolation & purification, Chlamydia trachomatis/immunology, Chlamydia trachomatis/isolation & purification, Humans, Immunity, Innate, Lymphogranuloma Venereum/immunology, Lymphogranuloma Venereum/prevention & control
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2014 17:17
Dernière modification de la notice
20/08/2019 15:52
Données d'usage