Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).

Détails

ID Serval
serval:BIB_D2A1F15C4F81
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).
Périodique
Annals of Nutrition and Metabolism
Auteur⸱e⸱s
Lescoat G., Desvergne B., Loreal O., Pasdeloup N., Deugnier Y., Bourel M., Brissot P.
ISSN
0250-6807 (Print)
ISSN-L
0250-6807
Statut éditorial
Publié
Date de publication
1989
Volume
33
Numéro
5
Pages
252-260
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Cocultured adult rat hepatocytes and a human hepatoma cell line (HepG2) were maintained in an arginine-free medium with or without ornithine alpha-ketoglutarate. This drug increased greatly hepatocyte albumin secretion in both culture models. L-Ornithine was the component accounting for these effects since similar data were obtained by using this sole amino acid. Moreover, we observed that L-ornithine stimulation of albumin production was via polyamine synthesis. Since a correlated increase in albumin mRNA was observed, it may be postulated that ornithine alpha-ketoglutarate acts at a pretranslational level.
Mots-clé
Albumins/secretion, Animals, Cells, Cultured, Humans, Liver/cytology, Liver/secretion, Liver Neoplasms, Experimental/pathology, Liver Neoplasms, Experimental/secretion, Ornithine/analogs & derivatives, Ornithine/pharmacology, Rats
Pubmed
Web of science
Création de la notice
24/01/2008 15:27
Dernière modification de la notice
20/08/2019 15:52
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