Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.

Détails

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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_D294B4AB5AC2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.
Périodique
Gynecologic Oncology
Auteur⸱e⸱s
Hwang W.T., Adams S.F., Tahirovic E., Hagemann I.S., Coukos G.
ISSN
1095-6859 (Electronic)
ISSN-L
0090-8258
Statut éditorial
Publié
Date de publication
2012
Volume
124
Numéro
2
Pages
192-198
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural Publication Status: ppublish
Résumé
OBJECTIVE: The presence of T cells within the epithelial component of tumors, as histologic evidence of anti-tumor immunity, has been associated with a survival advantage in multiple studies across diverse patient cohorts. We performed a meta-analysis of studies evaluating the prognostic value of tumor-infiltrating lymphocytes (TIL) on survival among women with ovarian cancer and to investigate factors associated with variations in this effect, including patient characteristics, surgical outcomes, tumor histology, and study protocols.
METHOD: Published studies that evaluated the association between TIL and patient survival were identified. Descriptive statistics, outcome data, and study quality were extracted from studies that met inclusion criteria. Hazard ratios and 95% confidence intervals were pooled across studies using the random-effects model. Publication bias was investigated using a funnel plot and heterogeneity was assessed with subgroup analysis and I(2) statistics.
RESULTS: Ten suitable studies comprising 1815 patients with ovarian cancer were analyzed. Our results demonstrate that a lack of intraepithelial TILs is significantly associated with a worse survival among patients (pooled HR: 2.24, 95% CI; 1.71-2.91). Variations in the prognostic value of TIL status based on debulking status, scoring method, and geographic regions were identified.
CONCLUSIONS: Intraepithelial TILs are a robust predictor of outcome in ovarian cancer and define a specific class of patients, whose distinct tumor biology should be taken into account in devising appropriate therapeutic strategies.
Mots-clé
Female, Humans, Lymphocytes, Tumor-Infiltrating/immunology, Ovarian Neoplasms/immunology, Prognosis
Pubmed
Web of science
Création de la notice
14/10/2014 12:42
Dernière modification de la notice
20/08/2019 16:52
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