Characterization of pretransplant CTL activity in "perfectly matched" unrelated bone marrow donor/recipient combinations.

Détails

ID Serval
serval:BIB_D268B9139C39
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Characterization of pretransplant CTL activity in "perfectly matched" unrelated bone marrow donor/recipient combinations.
Périodique
Bone Marrow Transplantation
Auteur(s)
Rufer N., Tiercy J.M., Speiser D., Helg C., Gratwohl A., Chapuis B., Jeannet M., Roosnek E.
ISSN
0268-3369 (Print)
ISSN-L
0268-3369
Statut éditorial
Publié
Date de publication
1993
Volume
11
Numéro
Suppl. 1
Pages
20-23
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To characterize the pre-transplant cytotoxic T cell precursor (CTLp) activity of unrelated bone marrow donors towards their HLA-ABDR compatible recipients, we have established T cell clones from the primary (positive) CTLp cultures. Two "perfectly matched" oligo-typed DR/DQ identical combinations and two A/B identical, DR subtype incompatible combinations have been studied in detail. Analysis of the clones shows that in the first two combinations the alloreactivity was directed towards a subtype of A2 (A205) and a subtype of Bw60 respectively. In the other two cases, where class II incompatibilities were present, we have not yet defined the exact specificity. However, because the majority of recipient specific clones were of the CD8 phenotype, it is very likely that also in these two cases differences in class I are being recognized.
Mots-clé
Antigens, CD8/analysis, Bone Marrow Transplantation/immunology, Cells, Cultured, HLA-DR Antigens/analysis, Histocompatibility/immunology, Histocompatibility Antigens Class I/analysis, Histocompatibility Testing, Humans, T-Lymphocytes, Cytotoxic/cytology, T-Lymphocytes, Cytotoxic/immunology, Tissue Donors
Pubmed
Web of science
Création de la notice
28/01/2008 12:33
Dernière modification de la notice
20/08/2019 16:52
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