High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis

Détails

ID Serval
serval:BIB_D20E53F22661
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis
Périodique
American Review of Respiratory Disease
Auteur⸱e⸱s
Suter  P. M., Suter  S., Girardin  E., Roux-Lombard  P., Grau  G. E., Dayer  J. M.
ISSN
1073-449X
0003-0805
Statut éditorial
Publié
Date de publication
05/1992
Volume
145
Numéro
5
Pages
1016-22
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
Intrapulmonary activation of leukocytes and release of cellular mediators and enzymes are involved in the pathophysiology of the adult respiratory distress syndrome (ARDS). To investigate a possible role of local cytokines, we measured bronchoalveolar fluid (BALF) and plasma levels of tumor necrosis factor alpha (TNF-alpha) and its soluble inhibitors (sTNF-RI + RII), interleukin-1 beta (IL-1 beta), interferon-alpha (IFN-alpha), and granulocyte elastase in 14 patients at risk for ARDS and in 35 patients developing ARDS after trauma, sepsis, or shock. During clinical development of severe ARDS, BALF cytokines increased markedly: TNF-alpha from 116 +/- 36 to 10,731 +/- 5,048 pg/ml (mean +/- SEM), p = 0.001; sTNF-RI + RII from 3.7 +/- 1.4 to 24.6 +/- 2.6 ng/ml, p less than 0.05; and IL-1 beta from 7,746 +/- 5,551 to 42,255 +/- 19,176 pg/ml, p = 0.01. Plasma cytokines were not increased in most patients, nor were they correlated with the development or severity of ARDS. BALF elastase was higher in patients developing ARDS than in those at risk but not going into pulmonary failure (0.97 +/- 0.26 versus 0.28 +/- 0.13 U/ml, p = 0.026), and the highest values were observed in the early stages of severe ARDS (1.85 +/- 0.39 U/ml). BALF elastase levels correlated with IFN-alpha (r = 0.72, p less than 0.001). In conclusion, local release of TNF-alpha and IL-1 beta, possibly by pulmonary macrophages or other cells, and/or accumulation in the lung is associated with the development of ARDS.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Bronchoalveolar Lavage Fluid/*chemistry Humans Infection/complications Interferon-alpha/*analysis Interleukin-1/*analysis Leukocyte Elastase Macrophages, Alveolar/*metabolism Multiple Trauma/complications Pancreatic Elastase/*analysis Respiratory Distress Syndrome, Adult/epidemiology/etiology/*metabolism Risk Factors Shock, Hemorrhagic/complications Tumor Necrosis Factor-alpha/*analysis/antagonists & inhibitors
Pubmed
Web of science
Création de la notice
15/01/2008 14:28
Dernière modification de la notice
20/08/2019 15:52
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