Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.

Détails

Ressource 1Télécharger: BIB_D1E04B8B1CBB.P001.pdf (511.93 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_D1E04B8B1CBB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
Périodique
PloS One
Auteur⸱e⸱s
Casado Concepcion, Colombo Sara, Rauch Andri, Martinez Raquel, Guenthard Huldrych F., Garcia Soledad, Rodriguez Carmen, del Romero Jorge, Telenti Amalio, Lopez-Galindez Cecilio
ISSN
1932-6203[electronic], 1932-6203[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
6
Pages
11079
Langue
anglais
Résumé
Background:
Various patterns of HIV-1 disease progression are described in clinical practice and in research. There is a need to assess the specificity of commonly used definitions of long term non-progressor (LTNP) elite controllers (LTNP-EC), viremic controllers (LTNP-VC), and viremic non controllers (LTNP-NC), as well as of chronic progressors (P) and rapid progressors (RP).
Methodology and Principal Findings:
We re-evaluated the HIV-1 clinical definitions, summarized in Table 1, using the information provided by a selected number of host genetic markers and viral factors. There is a continuous decrease of protective factors and an accumulation of risk factors from LTNP-EC to RP. Statistical differences in frequency of protective HLA-B alleles (p-0.01), HLA-C rs9264942 (p-0.06), and protective CCR5/CCR2 haplotypes (p-0.02) across groups, and the presence of viruses with an ancestral genotype in the "viral dating" (i.e., nucleotide sequences with low viral divergence from the most recent common ancestor) support the differences among principal clinical groups of HIV-1 infected individuals.
Conclusions:
A combination of host genetic and viral factors supports current clinical definitions that discriminate among patterns of HIV-1 progression. The study also emphasizes the need to apply a standardized and accepted set of clinical definitions for the purpose of disease stratification and research.
Mots-clé
Human-Immunodeficiency-Virus, Long-Term Nonprogressors, Treatment Interruptions, Antiretroviral Therapy, Replication Capacity, Type-1 Infection, Evolution, Heterogeneity, Controllers, Contribute
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/06/2010 8:16
Dernière modification de la notice
20/08/2019 15:52
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