Early retrograde effects of blocking axoplasmic transport in the axons of developing neurons.

Détails

ID Serval
serval:BIB_D1D2E0D23A27
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Early retrograde effects of blocking axoplasmic transport in the axons of developing neurons.
Périodique
Brain Research. Developmental Brain Research
Auteur(s)
Primi M.P., Clarke P.G.H.
ISSN
0165-3806[print], 0165-3806[linking]
Statut éditorial
Publié
Date de publication
1997
Volume
99
Numéro
2
Pages
259-262
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Apr 18
Résumé
Depriving developing neurons of retrograde trophic support may disrupt their development and often causes them to die. We here report the effects, in chick embryos, of eliminating retrograde support in the isthmo-optic projection by blocking axoplasmic transport in the terminal parts of the axons, which is known ultimately to kill the isthmo-optic neurons. Within only 9 h, this had perturbed the process of cellular reorganisation that eventually leads to the laminated appearance of the mature isthmo-optic nucleus. Neuron survival in the isthmo-optic nucleus was affected even more quickly, but the earliest change, occurring in as little as 3 h, was not an increase in the number of dying neurons, but a decrease below control values. This novel effect was still present at 6 and 9 h after the injection, but at longer survival times the number of dying neurons increased well above control values as expected. Our interpretation of the transient decrease in neuronal death is that retrograde trophic signals include both death-promoting and life-promoting components, and that the former act faster in this system.
Mots-clé
Animals, Axonal Transport/drug effects, Axonal Transport/physiology, Cell Count, Cell Death/physiology, Chick Embryo, Colchicine/pharmacology, Neurons/cytology, Neurons/physiology, Optic Nerve/cytology, Optic Nerve/embryology
Pubmed
Création de la notice
20/01/2008 17:48
Dernière modification de la notice
20/08/2019 15:51
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