Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.
Détails
ID Serval
serval:BIB_D1618479457A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.
Périodique
Cell Metabolism
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
15
Numéro
5
Pages
574-584
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this relationship are unknown, hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of protein kinase Cε as the mechanism responsible for NAFLD-associated hepatic insulin resistance seen in obesity, type 2 diabetes, and lipodystrophy.
Mots-clé
Animals, Diabetes Mellitus, Type 2/enzymology, Diabetes Mellitus, Type 2/metabolism, Diglycerides/metabolism, Fatty Liver/enzymology, Fatty Liver/metabolism, Humans, Insulin Resistance/physiology, Liver/metabolism, Mice, Non-alcoholic Fatty Liver Disease, Protein Kinase C-epsilon/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/09/2015 13:19
Dernière modification de la notice
20/08/2019 16:51
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