Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment

Détails

ID Serval
serval:BIB_D1145F215E7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment
Périodique
Circulation
Auteur(s)
Boutouyrie  P., Bussy  C., Hayoz  D., Hengstler  J., Dartois  N., Laloux  B., Brunner  H., Laurent  S.
ISSN
1524-4539 (Electronic)
Statut éditorial
Publié
Date de publication
06/2000
Volume
101
Numéro
22
Pages
2601-6
Notes
Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jun 6
Résumé
BACKGROUND: Local pulse pressure (PP) is an independent determinant of carotid artery wall thickness, stronger than mean blood pressure (BP). The present study was designed to assess whether a beta-adrenoceptor antagonist-based or an ACE inhibitor-based treatment was able to reduce carotid artery wall hypertrophy through a reduction in carotid PP rather than by lowering mean BP and whether the influence of local PP reduction could also be detected at the site of a muscular artery, the radial artery. METHODS AND RESULTS: Ninety-eight essential hypertensive patients were randomized to 9 months of double-blind treatment with either celiprolol or enalapril. Arterial parameters were determined with high-resolution echo-tracking systems. PP was measured locally with applanation tonometry and independently of mean BP. After 9 months of treatment, mean BP, carotid PP, and intimal-medial thickness (IMT) decreased significantly, with no difference between the 2 groups. The reduction in carotid PP but not in mean BP was a major independent determinant of the reduction in carotid IMT. Radial artery IMT and PP decreased significantly with both treatments. However, the reduction in radial artery IMT was not related to the changes in radial artery PP. CONCLUSIONS: The regression of carotid artery wall hypertrophy during long-term antihypertensive treatment was dependent on the reduction in local PP rather than on the lowering of mean BP. The effect of PP lowering on IMT reduction was observed at the site of an elastic artery but not at the site of a muscular artery.
Mots-clé
Adult Angiotensin-Converting Enzyme Inhibitors/administration & dosage Antihypertensive Agents/*administration & dosage *Blood Pressure Carotid Arteries/*pathology Celiprolol/*administration & dosage Elasticity Enalapril/administration & dosage Female Heart Rate Humans Hypertension/*drug therapy/*pathology Hypertrophy Male Middle Aged Regression Analysis Single-Blind Method
Pubmed
Web of science
Création de la notice
17/01/2008 17:38
Dernière modification de la notice
20/08/2019 16:51
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