The glucose transporter 2 regulates CD8<sup>+</sup> T cell function via environment sensing.

Détails

ID Serval
serval:BIB_D0F2621B2B52
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The glucose transporter 2 regulates CD8<sup>+</sup> T cell function via environment sensing.
Périodique
Nature metabolism
Auteur⸱e⸱s
Fu H., Vuononvirta J., Fanti S., Bonacina F., D'Amati A., Wang G., Poobalasingam T., Fankhaenel M., Lucchesi D., Coleby R., Tarussio D., Thorens B., Hearnden R.J., Longhi M.P., Grevitt P., Sheikh M.H., Solito E., Godinho S.A., Bombardieri M., Smith D.M., Cooper D., Iqbal A.J., Rathmell J.C., Schaefer S., Morales V., Bianchi K., Norata G.D., Marelli-Berg F.M.
ISSN
2522-5812 (Electronic)
ISSN-L
2522-5812
Statut éditorial
Publié
Date de publication
11/2023
Peer-reviewed
Oui
Volume
5
Numéro
11
Pages
1969-1985
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the glycolytic pathway are major checkpoints for this event. Here we show that the low-affinity, concentration-dependent glucose transporter 2 (Glut2) regulates the development of CD8 <sup>+</sup> T cell effector responses in mice by promoting glucose uptake, glycolysis and glucose storage. Expression of Glut2 is modulated by environmental factors including glucose and oxygen availability and extracellular acidification. Glut2 is highly expressed by circulating, recently primed T cells, allowing efficient glucose uptake and storage. In glucose-deprived inflammatory environments, Glut2 becomes downregulated, thus preventing passive loss of intracellular glucose. Mechanistically, Glut2 expression is regulated by a combination of molecular interactions involving hypoxia-inducible factor-1 alpha, galectin-9 and stomatin. Finally, we show that human T cells also rely on this glucose transporter, thus providing a potential target for therapeutic immunomodulation.
Mots-clé
Mice, Humans, Animals, Glucose/metabolism, Biological Transport/physiology, Glucose Transport Proteins, Facilitative/genetics, Glucose Transport Proteins, Facilitative/metabolism, Cell Differentiation, CD8-Positive T-Lymphocytes/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/10/2023 13:08
Dernière modification de la notice
13/12/2023 8:12
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