Choroidal Vascular Reactivity in Central Serous Chorioretinopathy.

Détails

ID Serval
serval:BIB_D0ED284C1264
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Choroidal Vascular Reactivity in Central Serous Chorioretinopathy.
Périodique
Investigative ophthalmology & visual science
Auteur(s)
Cardillo Piccolino F., Lupidi M., Cagini C., Fruttini D., Nicolò M., Eandi C.M., Tito S.
ISSN
1552-5783 (Electronic)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
01/08/2018
Peer-reviewed
Oui
Volume
59
Numéro
10
Pages
3897-3905
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To investigate by optical coherence tomography angiography (OCT-A) the choroidal vascular response to experimentally increased blood pressure in patients with central serous chorioretinopathy (CSCR).
For this multicenter, observational, case-control study, we enrolled 35 patients with an established diagnose of CSCR and 25 age-matched healthy controls. All subjects underwent a handgrip isometric exercise to obtain elevation of blood pressure (BP). In the resting phase and during the physical effort, macular OCT-angiograms were acquired. Systemic hemodynamic data were recorded at baseline and during stress conditions using an electronic sphygmomanometer. The analysis of vascular density (VD) of the choriocapillaris (CC) was performed on OCT-angiograms. The results obtained in CSCR patients, both at baseline and during the stress test, were compared with those of healthy subjects.
Baseline and under stress values of systolic BP, diastolic BP, and mean arterial pressure were significantly higher (P < 0.05) in CSCR patients compared to controls, reaching values in the range of hypertension during the exercise. Baseline VD values of the CC were significantly lower (P < 0.05) in CSCR cases compared to healthy subjects. We noticed a significant increase (P < 0.05) in these values under stress condition in CSCR patients and not in controls.
The present study suggests that choroidal blood flow is dysregulated in CSCR. During physical stress, CSCR patients easily reach critical values of BP that are not dampened by compensatory mechanisms in the choroidal vessels, as it happens in healthy subjects. The CC in CSCR could be particularly vulnerable to variations of systemic hemodynamics.
Mots-clé
Adult, Aged, Blood Pressure/physiology, Case-Control Studies, Central Serous Chorioretinopathy/physiopathology, Choroid/blood supply, Female, Fluorescein Angiography, Humans, Male, Middle Aged, Regional Blood Flow/physiology, Tomography, Optical Coherence
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/03/2021 20:17
Dernière modification de la notice
26/03/2021 7:35
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