Absence of homologous restriction factor does not affect CTL-mediated cytolysis
Détails
ID Serval
serval:BIB_D0D8EF03CD2E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Absence of homologous restriction factor does not affect CTL-mediated cytolysis
Périodique
European Journal of Immunology
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
01/1989
Volume
19
Numéro
1
Pages
217-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
Homologous restriction factor (HRF) is a membrane protein of erythrocytes and leukocytes that inhibits the complement (C5b-9)-mediated lysis in a species-restricting manner. HRF has also been reported to inhibit perforin-mediated cytolysis and postulated to play a role in cytotoxic T lymphocyte (CTL) self-protection. We show that paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes, lacking HRF, are no more sensitive to Ca2+-dependent human CTL-mediated lysis than normal erythrocytes. Furthermore, mouse and normal human erythrocytes, as well as PNH erythrocytes, are similarly lysed by isolated murine perforin-containing granules. We conclude that HRF does not inhibit perforin-mediated lysis and therefore is not likely to play a role in CTL self-protection.
Mots-clé
*Antigens, CD59
Blood Proteins/*deficiency
*Carrier Proteins
Complement System Proteins/physiology
*Cytotoxicity, Immunologic
Hemoglobinuria, Paroxysmal/blood/immunology
Hemolysis
Humans
*Membrane Glycoproteins
Membrane Proteins/blood/*deficiency/physiology
Pore Forming Cytotoxic Proteins
Species Specificity
T-Lymphocytes, Cytotoxic/*immunology/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 16:51