Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.

Détails

ID Serval
serval:BIB_D0C5F473C657
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Périodique
Trends in Immunology
Auteur(s)
Rebeaud F., Hailfinger S., Thome M.
ISSN
1471-4906[print], 1471-4906[linking]
Statut éditorial
Publié
Date de publication
2007
Volume
28
Numéro
5
Pages
196-200
Langue
anglais
Résumé
Mitogen-activated protein kinases (MAPKs), including p38 and c-Jun N-terminal kinase (JNK), have a key role in T cell receptor (TCR)-induced gene transcription but their precise mechanism of activation is not well understood. The findings of two recent papers provide new insight into the activation of p38 and JNK by the membrane-associated guanylate kinase (MAGUK) family members Dlgh1 and Carma1, respectively, and show how distinct MAGUK proteins control specific aspects of TCR-mediated MAPK activation.
Mots-clé
Adaptor Proteins, Signal Transducing/metabolism, Animals, Apoptosis Regulatory Proteins/metabolism, CARD Signaling Adaptor Proteins/metabolism, Cell Line, Enzyme Activation, Humans, MAP Kinase Kinase 4/metabolism, Membrane Proteins/metabolism, Mice, Mitogen-Activated Protein Kinases/metabolism, Receptors, Antigen, T-Cell/metabolism, Signal Transduction, T-Lymphocytes/immunology, p38 Mitogen-Activated Protein Kinases/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:11
Dernière modification de la notice
20/08/2019 16:51
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