Histological and immunohistochemical revision of hepatocellular adenomas: a learning experience.

Détails

ID Serval
serval:BIB_D0BAD8E8F1AE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Histological and immunohistochemical revision of hepatocellular adenomas: a learning experience.
Périodique
International Journal of Hepatology
Auteur(s)
Fonseca S., Hoton D., Dardenne S., Annet L., Hubert C., Godecharles S., Jouret-Mourin A., Reding R., Otte J.B., Rahier J., Gigot J.F., Sempoux C.
ISSN
2090-3448 (Print)
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
2013
Pages
398308
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1 α -inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β -catenin-activated HCA (b-HCA). We reviewed retrospectively our surgical HCA series to learn how to recognize the different subtypes histopathologically and how to interpret adequately their immunohistochemical staining. From January 1992 to January 2012, 37 patients underwent surgical resection for HCA in our institution. Nine had H-HCA (25%) characterized by steatosis and loss of L-FABP expression; 20 had IHCA (55.5%) showing CRP and/or SAA expression, sinusoidal dilatation, and variable inflammation; and 1 patient had both H-HCA and IHCA. In 5 patients (14%), b-HCA with GS and β -catenin nuclear positivity was diagnosed, two already with hepatocellular carcinoma. Two cases (5.5%) remained unclassified. One of the b-HCA showed also the H-HCA histological and immunohistochemical characteristics suggesting a subgroup of β -catenin-activated/HNF1 α -inactivated HCA, another b-HCA exhibited the IHCA histological and immunohistochemical characteristics suggesting a subgroup of β -catenin-activated/inflammatory HCA. Interestingly, three patients had underlying vascular abnormalities. Using the recently published criteria enabled us to classify histopathologically our retrospective HCA surgical series with accurate recognition of b-HCA for which we confirm the higher risk of malignant transformation. We also underlined the association between HCA and vascular abnormalities.
Pubmed
Open Access
Oui
Création de la notice
19/01/2015 12:14
Dernière modification de la notice
20/08/2019 16:50
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