TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study.

Détails

ID Serval
serval:BIB_D0985E1809F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study.
Périodique
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Auteur(s)
Kimiskidis V.K., Tsimpiris A., Ryvlin P., Kalviainen R., Koutroumanidis M., Valentin A., Laskaris N., Kugiumtzis D.
ISSN
1872-8952 (Electronic)
ISSN-L
1388-2457
Statut éditorial
Publié
Date de publication
02/2017
Peer-reviewed
Oui
Volume
128
Numéro
2
Pages
367-381
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
(A) To develop a TMS-EEG stimulation and data analysis protocol in genetic generalized epilepsy (GGE). (B) To investigate the diagnostic accuracy of TMS-EEG in GGE.
Pilot experiments resulted in the development and optimization of a paired-pulse TMS-EEG protocol at rest, during hyperventilation (HV), and post-HV combined with multi-level data analysis. This protocol was applied in 11 controls (C) and 25 GGE patients (P), further dichotomized into responders to antiepileptic drugs (R, n=13) and non-responders (n-R, n=12).Features (n=57) extracted from TMS-EEG responses after multi-level analysis were given to a feature selection scheme and a Bayesian classifier, and the accuracy of assigning participants into the classes P-C and R-nR was computed.
On the basis of the optimal feature subset, the cross-validated accuracy of TMS-EEG for the classification P-C was 0.86 at rest, 0.81 during HV and 0.92 at post-HV, whereas for R-nR the corresponding figures are 0.80, 0.78 and 0.65, respectively. Applying a fusion approach on all conditions resulted in an accuracy of 0.84 for the classification P-C and 0.76 for the classification R-nR.
TMS-EEG can be used for diagnostic purposes and for assessing the response to antiepileptic drugs.
TMS-EEG holds significant diagnostic potential in GGE.

Pubmed
Web of science
Création de la notice
08/01/2017 16:13
Dernière modification de la notice
20/08/2019 16:50
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