Imaging transient, randomly occurring neuropsychological events in single subjects with positron emission tomography: an event-related count rate correlational analysis.

Détails

ID Serval
serval:BIB_D04E2733D2F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Imaging transient, randomly occurring neuropsychological events in single subjects with positron emission tomography: an event-related count rate correlational analysis.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Silbersweig D.A., Stern E., Schnorr L., Frith C.D., Ashburner J., Cahill C., Frackowiak R.S., Jones T.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1994
Volume
14
Numéro
5
Pages
771-782
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Many neuropsychiatric symptom states are idiosyncratic, involuntary, randomly occurring, subjective, and transient. The brain states associated with these clinically important mental states cannot be imaged directly with existing positron emission tomography (PET) techniques. A new PET method that brings such mental/brain states under experimental control for analysis in single subjects is described. It utilizes a slow bolus H2 15O three-dimensional (3D) regional CBF imaging technique. The analysis focuses upon natural or experimentally induced variance in the temporal distribution of specific neuropsychological events over the course of a study session. For each scan, the amount of radioactivity entering the brain during these events is calculated to derive a score reflecting the contribution of the events to the image. A statistical analysis is then performed to identify those pixels in which the intensity covaries with the scan scores over the subject's scans. This permits the identification of the brain areas associated with the mental state of interest. The method is validated using an auditory sentence-monitoring task. The detection in single subjects of cerebral activations associated with recurrent events as brief as 2 s in duration is demonstrated. This method may be used as a means of imaging ephemeral neurologic or neuropsychiatric symptom states or as an alternative to a subtraction design for activation studies.
Mots-clé
Adult, Brain/physiology, Brain/radionuclide imaging, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance/physiology, Reproducibility of Results, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/09/2011 20:41
Dernière modification de la notice
20/08/2019 15:50
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