Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

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ID Serval
serval:BIB_D0474EC65CDA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.
Périodique
Cell reports
Auteur(s)
Bowman R.L., Klemm F., Akkari L., Pyonteck S.M., Sevenich L., Quail D.F., Dhara S., Simpson K., Gardner E.E., Iacobuzio-Donahue C.A., Brennan C.W., Tabar V., Gutin P.H., Joyce J.A.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
22/11/2016
Peer-reviewed
Oui
Volume
17
Numéro
9
Pages
2445-2459
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of different macrophage populations affect their roles in malignancy. Given potential artifacts associated with irradiation-based lineage tracing, it remains unclear if bone-marrow-derived macrophages (BMDMs) are present in tumors of the brain, a tissue with no homeostatic involvement of BMDMs. Here, we employed multiple models of murine brain malignancy and genetic lineage tracing to demonstrate that BMDMs are abundant in primary and metastatic brain tumors. Our data indicate that distinct transcriptional networks in brain-resident microglia and recruited BMDMs are associated with tumor-mediated education yet are also influenced by chromatin landscapes established before tumor initiation. Furthermore, we demonstrate that microglia specifically repress Itga4 (CD49D), enabling its utility as a discriminatory marker between microglia and BMDMs in primary and metastatic disease in mouse and human.
Mots-clé
Animals, Base Sequence, Bone Marrow Cells/pathology, Brain Neoplasms/genetics, Brain Neoplasms/pathology, Cell Lineage, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Glioma/genetics, Glioma/pathology, Humans, Integrin alpha4/metabolism, Macrophage Activation, Macrophages/metabolism, Macrophages/pathology, Mice, Microglia/metabolism, Microglia/pathology, Sequence Analysis, RNA, Transcription Factors/metabolism, CD49D, Macrophage, brain metastasis, glioma, microglia, tumor-associated macrophages
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/12/2016 19:28
Dernière modification de la notice
07/04/2021 6:34
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