Determination of peak trabecular bone density: interplay of dietary fiber, carbohydrate, and androgens

Détails

ID Serval
serval:BIB_D033BAB6A0CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Determination of peak trabecular bone density: interplay of dietary fiber, carbohydrate, and androgens
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Leuenberger  P. K., Buchanan  J. R., Myers  C. A., Lloyd  T., Demers  L. M.
ISSN
0002-9165 (Print)
Statut éditorial
Publié
Date de publication
11/1989
Volume
50
Numéro
5
Pages
955-61
Notes
Journal Article --- Old month value: Nov
Résumé
To elucidate mechanisms linking nutrition and sex hormones to magnitude of peak trabecular bone density, we studied 11 normal women aged 19-21 y. Trabecular bone density was related inversely to dietary fiber (r = -0.69, p = 0.02) and carbohydrate (r = -0.70, p = 0.02) and directly to serum free-and-albumin-bound testosterone (fab T) (r = -0.70, p = 0.02) and total testosterone (total T) (r = 0.66, p = 0.03). Dietary fiber was correlated negatively with fab T (r = -0.74, p = 0.009), total T (r = -0.70, p = 0.02), and androstenedione (Adione) (r = -0.72, p = 0.01). Controlling for the effect of fab T or Adione weakened the relationship between dietary fiber and bone density and the relationship was no longer statistically significant. Conversely, controlling for sex hormones did not abolish the effect of carbohydrate on bone density. The contributions of fab T and carbohydrate to bone density were independent. These results suggest that dietary fiber may depress serum androgens which in turn decrease trabecular bone density. Carbohydrate may also depress bone density but independently of sex steroid hormones.
Mots-clé
Adult Androgens/*blood *Bone Density Bone and Bones/*metabolism Dietary Carbohydrates/*pharmacology Dietary Fiber/*pharmacology Female Humans Serum Albumin/metabolism Testosterone/blood
Pubmed
Web of science
Création de la notice
25/01/2008 9:50
Dernière modification de la notice
20/08/2019 15:50
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