Immunohistochemical analysis of a cerebral arteriovenous malformation obliterated by radiosurgery and presenting with re-bleeding. Case report.
Détails
ID Serval
serval:BIB_CFFC90C55AE0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Immunohistochemical analysis of a cerebral arteriovenous malformation obliterated by radiosurgery and presenting with re-bleeding. Case report.
Périodique
Neurological Research
ISSN
0161-6412 (Print)
ISSN-L
0161-6412
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
25
Numéro
7
Pages
718-721
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The purpose of this study was to analyze immunohistochemical characteristics of the cell population in a radiosurgically obliterated cerebral arteriovenous malformation (AVM) after recurrent hemorrhage. Immunohistochemical reactions were carried out on paraffin-embedded histological sections for von Willebrand factor (FVIII), CD34 endothelial antigen (CD34), vimentin and alpha-smooth-muscle actin (SMA) cytoskeletal proteins. Histopathological analysis revealed that the majority of AVM channels were replaced by hypocellular scar tissue. However some of them still disclosed thrombus organization by granulation tissue seven years after radiosurgery. FVIII and CD34 reactions revealed vessel neoformation in thromboses. Proliferating spindle-shaped cells with SMA and vimentin expression were identified in the granulation tissue. These histopathological findings suggest the role of re-canalization in recurrence of hemorrhage following radiosurgical obliteration of the AVM. Contribution of myofibroblastic elements in the vessels' occlusion after radiosurgery is also demonstrated.
Mots-clé
Adult, Cerebral Hemorrhage/diagnosis, Cerebral Hemorrhage/physiopathology, Diagnosis, Differential, Humans, Immunohistochemistry, Intracranial Arteriovenous Malformations/diagnosis, Intracranial Arteriovenous Malformations/physiopathology, Male, Radiosurgery/methods, Recurrence/prevention & control
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
20/08/2019 16:50