Exploring genetic suppression interactions on a global scale.

Détails

ID Serval
serval:BIB_CF7164F33625
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Exploring genetic suppression interactions on a global scale.
Périodique
Science
Auteur⸱e⸱s
van Leeuwen J., Pons C., Mellor J.C., Yamaguchi T.N., Friesen H., Koschwanez J., Ušaj M.M., Pechlaner M., Takar M., Ušaj M., VanderSluis B., Andrusiak K., Bansal P., Baryshnikova A., Boone C.E., Cao J., Cote A., Gebbia M., Horecka G., Horecka I., Kuzmin E., Legro N., Liang W., van Lieshout N., McNee M., San Luis B.J., Shaeri F., Shuteriqi E., Sun S., Yang L., Youn J.Y., Yuen M., Costanzo M., Gingras A.C., Aloy P., Oostenbrink C., Murray A., Graham T.R., Myers C.L., Andrews B.J., Roth F.P., Boone C.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
04/11/2016
Peer-reviewed
Oui
Volume
354
Numéro
6312
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Genetic suppression occurs when the phenotypic defects caused by a mutation in a particular gene are rescued by a mutation in a second gene. To explore the principles of genetic suppression, we examined both literature-curated and unbiased experimental data, involving systematic genetic mapping and whole-genome sequencing, to generate a large-scale suppression network among yeast genes. Most suppression pairs identified novel relationships among functionally related genes, providing new insights into the functional wiring diagram of the cell. In addition to suppressor mutations, we identified frequent secondary mutations,in a subset of genes, that likely cause a delay in the onset of stationary phase, which appears to promote their enrichment within a propagating population. These findings allow us to formulate and quantify general mechanisms of genetic suppression.
Mots-clé
Cell Physiological Phenomena/genetics, Chromosome Mapping, Gene Regulatory Networks, Genes, Fungal, Genes, Suppressor, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae Proteins/genetics, Suppression, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2019 15:56
Dernière modification de la notice
21/08/2019 5:35
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