Alveolar haemorrhage syndromes

Détails

ID Serval
serval:BIB_CF683C158D56
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Institution
Titre
Alveolar haemorrhage syndromes
Titre du livre
Orphan Lung Diseases
Auteur(s)
Lazor R.
Editeur
European Respiratory Society
Lieu d'édition
Plymouth
ISBN
ISBN: 978-1-84984-013-2
Statut éditorial
Publié
Date de publication
2011
Editeur scientifique
Cordier J.F.
Volume
54
Série
European Respiratory Society Monograph
Numéro de chapitre
2
Pages
15-31
Langue
anglais
Résumé
Alveolar haemorrhage (AH) is a rare and potentially life-threatening condition characterised by diffuse blood leakage from the pulmonary microcirculation into the alveolar spaces due to microvascular damage. It is not a single disease but a clinical syndrome that may have numerous causes. Autoimmune disorders account for fewer than half of cases, whereas the majority are due to nonimmune causes such as left heart disease, infections, drug toxicities, coagulopathies and malignancies. The clinical picture includes haemoptysis, diffuse alveolar opacities at imaging and anaemia. Bronchoalveolar lavage is the gold standard method for diagnosing AH. The lavage fluid appears macroscopically haemorrhagic and/or contains numerous haemosiderin-laden macrophages. The diagnostic work-up includes search for autoimmune disorders, review of drugs and exposures, assessment of coagulation and left heart function, and search for infectious agents. Renal biopsy is often indicated if AH is associated with renal involvement, whereas lung biopsy is only rarely useful. Therapy aims at correction of reversible factors and immunosuppressive therapy in autoimmune causes, with plasmapheresis in selected situations.
Création de la notice
21/03/2012 0:28
Dernière modification de la notice
20/08/2019 16:49
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