Effect of orlistat in obese patients with binge eating disorder.

Détails

ID Serval
serval:BIB_CF4ACC8C36A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of orlistat in obese patients with binge eating disorder.
Périodique
Obesity Research
Auteur⸱e⸱s
Golay A., Laurent-Jaccard A., Habicht F., Gachoud J.P., Chabloz M., Kammer A., Schutz Y.
ISSN
1071-7323 (Print)
ISSN-L
1071-7323
Statut éditorial
Publié
Date de publication
10/2005
Volume
13
Numéro
10
Pages
1701-1708
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: Binge eating disorder represents a significant public health problem, with up to 50% of weight loss program participants displaying this disorder. In previous studies with orlistat, patients with binge eating disorder were excluded. The goal of this study was to assess the efficacy of orlistat in obese patients with binge eating disorder.
RESEARCH METHODS AND PROCEDURES: Eighty-nine patients with clinically diagnosed binge eating disorder and a BMI > or = 30 kg/m2 were randomized in double-blind fashion to 24 weeks of treatment with 120 mg of orlistat or placebo three times daily, in combination with a mildly reduced-calorie diet.
RESULTS: After 24 weeks, the mean weight loss from baseline for orlistat-treated patients was significantly greater than for patients receiving placebo (-7.4% vs. -2.3%; p = 0.0001) (intent-to-treat analysis). The overall Eating Disorder Inventory 2 score at week 24 was significantly lower in patients treated with orlistat than in those in the placebo group (p = 0.011).
DISCUSSION: Orlistat may be considered as part of the management for patients with obesity and binge eating disorder.
Mots-clé
Anthropometry, Anti-Obesity Agents/therapeutic use, Anxiety/complications, Bulimia/drug therapy, Depression/complications, Double-Blind Method, Humans, Lactones/therapeutic use, Obesity/complications, Obesity/drug therapy, Placebos, Weight Loss
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 13:08
Dernière modification de la notice
20/08/2019 15:49
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