Continuous electroencephalographic monitoring in critically ill patients with central nervous system infections.

Détails

ID Serval
serval:BIB_CF4AA70ED2AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Continuous electroencephalographic monitoring in critically ill patients with central nervous system infections.
Périodique
Archives of Neurology
Auteur⸱e⸱s
Carrera E., Claassen J., Oddo M., Emerson R.G., Mayer S.A., Hirsch L.J.
ISSN
1538-3687[electronic]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
65
Numéro
12
Pages
1612-1618
Langue
anglais
Résumé
OBJECTIVES: To determine the prevalence, predictors, and clinical significance of electrographic seizures (ESz) and other continuous electroencephalographic monitoring findings in critically ill patients with central nervous system infections. DESIGN: Retrospective cohort study. SETTING: Eighteen-bed neurocritical care unit. PATIENTS: We identified 42 consecutive patients with primary central nervous system infection (viral, 27 patients [64%]; bacterial, 8 patients [18%]; and fungal or parasitic, 7 patients [17%]) who underwent continuous electroencephalographic monitoring between January 1, 1996, and February 28, 2007. MAIN OUTCOME MEASURES: Presence of ESz or periodic epileptiform discharges (PEDs). RESULTS: Electrographic seizures were recorded in 14 patients (33%), and PEDs were recorded in 17 patients (40%). Twenty patients (48%) had either PEDs or ESz. Of the 14 patients with ESz, only 5 (36%) had a clinical correlate. Periodic epileptiform discharges (odds ratio=13.4; P=.001) and viral cause (odds ratio=13.0; P=.02) were independently associated with ESz. Both ESz (odds ratio=5.9; P=.02) and PEDs (odds ratio=6.1; P=.01) were independently associated with poor outcome at discharge (severe disability, vegetative state, or death). CONCLUSIONS: In patients with central nervous system infections undergoing continuous electroencephalographic monitoring, ESz and/or PEDs were frequent, occurring in 48% of our cohort. More than half of the ESz had no clinical correlate. Both ESz and PEDs were independently associated with poor outcome. Additional studies are needed to determine whether prevention or treatment of these electrographic findings improves outcome.
Mots-clé
Adolescent, Adult, Aged, Central Nervous System Infections/classification, Central Nervous System Infections/drug therapy, Chi-Square Distribution, Cohort Studies, Critical Illness, Electroencephalography/methods, Female, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Monitoring, Physiologic/methods, Retrospective Studies, Seizures/etiology, Statistics, Nonparametric, X-Ray Microtomography/methods, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/12/2009 12:32
Dernière modification de la notice
20/08/2019 15:49
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