The extra-splanchnic fructose escape after ingestion of a fructose-glucose drink: An exploratory study in healthy humans using a dual fructose isotope method.

Détails

ID Serval
serval:BIB_CF33A6A42735
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The extra-splanchnic fructose escape after ingestion of a fructose-glucose drink: An exploratory study in healthy humans using a dual fructose isotope method.
Périodique
Clinical nutrition ESPEN
Auteur(s)
Francey C., Cros J., Rosset R., Crézé C., Rey V., Stefanoni N., Schneiter P., Tappy L., Seyssel K.
ISSN
2405-4577 (Electronic)
ISSN-L
2405-4577
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
29
Pages
125-132
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The presence of specific fructose transporters and fructose metabolizing enzymes has now been demonstrated in the skeletal muscle, brain, heart, adipose tissue and many other tissues. This suggests that fructose may be directly metabolized and play physiological or pathophysiological roles in extra-splanchnic tissues. Yet, the proportion of ingested fructose reaching the systemic circulation is generally not measured. This study aimed to assess the amount of oral fructose escaping first-pass splanchnic extraction after ingestion of a fructose-glucose drink using a dual oral-intravenous fructose isotope method.
Nine healthy volunteers were studied over 2 h before and 4 h after ingestion of a drink containing 30.4 ± 1.0 g of glucose (mean ± SEM) and 30.4 ± 1.0 g of fructose labelled with 1% [U- <sup>13</sup> C <sub>6</sub> ]-fructose. A 75%-unlabeled fructose and 25%-[6,6- <sup>2</sup> H <sub>2</sub> ]-fructose solution was continuously infused (100 μg kg <sup>-1</sup> min <sup>-1</sup> ) over the 6 h period. Total systemic, oral and endogenous fructose fluxes were calculated from plasma fructose concentrations and isotopic enrichments. The fraction of fructose escaping first-pass splanchnic extraction was calculated assuming a complete intestinal absorption of the fructose drink.
Fasting plasma fructose concentration before tracer infusion was 17.9 ± 0.6 μmol.L <sup>-1</sup> . Fasting endogenous fructose production detected by tracer dilution analysis was 55.3 ± 3.8 μg kg <sup>-1</sup> min <sup>-1</sup> . Over the 4 h post drink ingestion, 4.4 ± 0.2 g of ingested fructose (i.e. 14.5 ± 0.8%) escaped first-pass splanchnic extraction and reached the systemic circulation. Endogenous fructose production significantly increased to a maximum of 165.4 ± 10.7 μg kg <sup>-1</sup> ·min <sup>-1</sup> 60 min after drink ingestion (p < 0.001).
These data indicate that a non-negligible fraction of fructose is able to escape splanchnic extraction and circulate in the periphery. The metabolic effects of direct fructose metabolism in extra-splanchnic tissues, and their relationship with metabolic diseases, remain to be evaluated. Our results also open new research perspectives regarding the physiological role of endogenous fructose production.
Mots-clé
Adult, Blood Glucose, Eating/physiology, Fasting, Female, Fructose/administration & dosage, Fructose/blood, Fructose/metabolism, Glucose/metabolism, Humans, Isotopes, Male, Sugar-Sweetened Beverages, Young Adult, Fructose metabolism, Human physiology, Isotope tracers
Pubmed
Web of science
Création de la notice
18/02/2019 11:42
Dernière modification de la notice
27/04/2020 6:20
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