T cells as a therapeutic target in SLE.

Détails

ID Serval
serval:BIB_CF302EF01784
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
T cells as a therapeutic target in SLE.
Périodique
Lupus
Auteur⸱e⸱s
Comte D., Karampetsou M.P., Tsokos G.C.
ISSN
1477-0962 (Electronic)
ISSN-L
0961-2033
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
24
Numéro
4-5
Pages
351-363
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by a loss of tolerance to multiple endogenous antigens. SLE etiology remains largely unknown, despite recent insight into the immunopathogenesis of the disease. T cells are important in the development of the disease by amplifying the immune response and contributing to organ damage. Aberrant signaling, cytokine secretion, and tissue homing displayed by SLE T cells have been extensively studied and the underlying pathogenic molecular mechanisms are starting to be elucidated. T-cell-targeted treatments are being explored in SLE patients. This review is an update on the T-cell abnormalities and related therapeutic options in SLE.
Pubmed
Web of science
Création de la notice
28/04/2015 17:09
Dernière modification de la notice
06/03/2020 6:20
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