Allergen-specific immunotherapy of allergy and asthma: current and future trends.

Détails

ID Serval
serval:BIB_CF19BFEC7031
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Allergen-specific immunotherapy of allergy and asthma: current and future trends.
Périodique
Expert Review of Respiratory Medicine
Auteur(s)
Spertini F., Reymond C., Leimgruber A.
ISSN
1747-6356 (Electronic)
ISSN-L
1747-6348
Statut éditorial
Publié
Date de publication
2009
Volume
3
Numéro
1
Pages
37-51
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Allergen-specific immunotherapy is the only immunomodulatory and etiological therapy of allergy and asthma. Conventional specific immunotherapy (SIT) with whole-allergen extract is antigen specific, effective on multiple organs, efficient on asthma in defined conditions, provides long-lasting protection and is cost effective. Moreover, SIT is able to prevent the course of rhinitis to asthma. SIT has its drawbacks: the long duration of treatment, the unsatisfactory standardization of allergen extracts and a questionable safety level. Novel approaches are aimed at drastically reducing adverse anaphylactic events, shortening the duration of therapy and improving its efficacy. Novel promising approaches have based their formulation on a limited set of recombinant allergens or chimeric molecules as well as on hypoallergenic allergen fragments or peptides. The simultaneous use of adjuvants with immunomodulatory properties may contribute to improve both the safety and efficacy of allergen-SIT of allergy and asthma.
Pubmed
Création de la notice
11/09/2011 14:39
Dernière modification de la notice
20/08/2019 16:49
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