Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism.

Détails

ID Serval
serval:BIB_CEF8981E0F90
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impaired glucose tolerance and diabetes in obesity: a 6-year follow-up study of glucose metabolism.
Périodique
Metabolism: Clinical and Experimental
Auteur(s)
Jallut D., Golay A., Munger R., Frascarolo P., Schutz Y., Jéquier E., Felber J.P.
ISSN
0026-0495 (Print)
ISSN-L
0026-0495
Statut éditorial
Publié
Date de publication
1990
Volume
39
Numéro
10
Pages
1068-1075
Langue
anglais
Résumé
To investigate the time course of glucose metabolism in obesity 33 patients (21 to 69 years old; body mass index [BMI], 25.7 to 53.3 kg/m2) with different degrees of glucose intolerance or diabetes who had been studied initially and 6 years later were submitted to the same 100-g oral glucose tolerance test (OGTT) with indirect calorimetry. From a group of 13 obese subjects with normal glucose tolerance (NGT), four developed impaired glucose tolerance (IGT); from a group of nine patients with IGT, three developed non-insulin-dependent diabetes mellitus (NIDDM); five of six obese NIDDM subjects with high insulin response developed NIDDM with low insulin response. Five patients had diabetes with hypoinsulinemia initially. As previously seen in a cross-sectional study, the 3-hour glucose storage measured by continuous indirect calorimetry remained unaltered in patients with IGT, whereas it decreased in NIDDM patients. A further decrease in glucose storage was observed with the lowering of the insulin response in the previously hyperinsulinemic diabetics. These results confirm cross-sectional studies that suggest successive phases in the evolution of obesity to diabetes: A, NGT; B, IGT (the hyperglycemia normalizing the glucose storage over 3 hours); C, diabetes with increased insulin response, where hyperglycemia does not correct the resistance to glucose storage anymore; and D, diabetes with low insulin response, with a low glucose storage and an elevated fasting and postload glycemia.
Mots-clé
Adult, Aged, Blood Glucose/analysis, Diabetes Mellitus/metabolism, Diabetes Mellitus, Type 2/etiology, Diabetes Mellitus, Type 2/metabolism, Female, Follow-Up Studies, Glucose/metabolism, Glucose Tolerance Test, Humans, Insulin/blood, Male, Middle Aged, Obesity
Pubmed
Web of science
Création de la notice
21/01/2008 14:09
Dernière modification de la notice
20/08/2019 16:49
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