Molecular techniques in the diagnosis of drug-resistant tuberculosis

Détails

ID Serval
serval:BIB_CEA775982977
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular techniques in the diagnosis of drug-resistant tuberculosis
Périodique
Annals of the Academy of Medicine, Singapore
Auteur⸱e⸱s
Alcaide  F., Telenti  A.
ISSN
0304-4602 (Print)
Statut éditorial
Publié
Date de publication
09/1997
Volume
26
Numéro
5
Pages
647-50
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Résumé
In the last few years, there has been considerable progress in our understanding of the mechanisms of action and resistance to anti-tuberculosis agents. To date, there is information about 11 genes involved in resistance to all major anti-tuberculous drugs in Mycobacterium tuberculosis. Mutations in katG, inhA and ahpC genes are found in up to 90% of isoniazid-resistant strains, rifampin resistance is associated (> 96%) with rpoB mutations, pyrazinamide resistance with pncA mutations (72% to 97%), ethambutol resistance with mutations in embB (47% to 65%), streptomycin resistance with rrs or rpsL mutations (70%), and fluoroquinolone resistance with gyrA substitutions (75% to 94%). Additional genes and mechanisms may play a role, particularly in association with lower levels of resistance. Based on this growing set of information, genotypic analysis of resistance is becoming a real possibility, and novel tests are being developed. Issues such as effectiveness, cost-efficiency, and appropriate setting for the implementation of these techniques are not yet established.
Mots-clé
Antitubercular Agents/therapeutic use Genotype Humans Mutation Mycobacterium tuberculosis/*drug effects/*genetics Polymerase Chain Reaction Tuberculosis, Multidrug-Resistant/*drug therapy/genetics
Pubmed
Création de la notice
25/01/2008 14:46
Dernière modification de la notice
20/08/2019 15:49
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